Research and Keynotes

DISCLAMER:

NOTE: This section contains research and testimony of medical professionals, practitioners and other organizations. The views, opinions and data expressed here are for educational purposes only, and do not warrant the opinions of TalkOnDiabetes.org, the TalkOnDiabetes Foundation, or any affilates or associating organizations. Please read the disclaimer first before continuing.

CLINICAL NOTES

Erythropoietin in Kidney Disease and Type 2 Diabetes
In a secondary analysis of the Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT), Solomon et al. (Sept. 16 issue)1 report that the quartile of patients who had the lowest hematopoietic response to darbepoetin alfa had the highest risk of death or cardiovascular events. 

Double Transplantation Treatment for Type 1 Diabetes
City of Hope researchers have found that bone marrow transplantation with islet cell transplantation shows promise as a treatment for late-stage type 1diabetes. 

Rogue Protein May Trigger Diabetes
The presence of amyloid protein may produce a chain reaction which destroys vital insulin-producing cells.

Surgeons Create Functional Artificial Pancreatic Tissue
In a proof-of-concept study presented at the 2010 Annual Clinical Congress of the American College of Surgeons, the researchers note that the matrix not only helps to understand the micro-architecture of the pancreas, but also prolongs the survival and preserves the function of the islets. Islets survived longer in the bio-artificial matrix than in conventional transplantation sites, and they produced significantly more insulin when challenged with glucose.

The Story of GAD
You may not have heard of GAD, but it's a hot topic in the world of type 1 diabetes research. GAD, which stands for glutamic acid decarboxylase, is an enzyme in the brain and the pancreas that plays several roles in the body

ALTERNATIVE RESEARCH

Research on Stevia - Natural Sweetener

Stevia has garnered attention with the rise in demand for low-carbohydrate, low-sugar food alternatives. Stevia also has shown promise in medical research for treating such conditions as obesity and high blood pressure. Stevia has a negligible effect on blood glucose, even enhancing glucose tolerance; therefore, it is attractive as a natural sweetener to diabetics and others on carbohydrate-controlled diets.

 Studies showed no adverse effects of steviol glycosides when taken at doses of about 4 mg per day.  In December 2008, the US Food and Drug Administration (US FDA) stated it had no objection to the conclusion of an expert panel that rebaudioside A is generally recognized as safe (GRAS) for use as a general purpose sweetener.  Prior to this, stevia-based ingredients were only permitted for use as a dietary supplement in the U.S.  Scientific data on steviol glycosides, including rebaudioside A (used in rebiana) and concluded that they are safe for their intended use - to sweeten foods and beverages and established a permanent Acceptable Daily Intake (ADI) level.  Click here For more details.

Canadian Diabetes Association National Nutrition Committee Technical Review: Non-nutritive Intense Sweeteners in Diabetes Management

A Compilation of the Current and Past Evidence Regarding Stevia 

JOINT FAO/WHO EXPERT COMMITTEE ON FOOD ADDITIVES, 17-26 June 2008

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Einstein College of Medicine Receives $600,000 Grant to Study Resveratrol's Impact on Pre-Diabetes

The Albert Einstein College of Medicine at Yeshiva University in New York City has received a $600,000 grant from the AmericanDiabetes Association to study the effects of resveratrol on lowering impaired glucose tolerance in older adults.

Impaired glucose tolerance-the inability to use insulin properly-is one of the main conditions of pre-diabetes. According to the ADA, almost 40 percent of adults over age 60 have IGT or diabetes. Pre-diabetes itself, says the association, increases the risk of heart attack or stroke by 50 percent.

Resveratrol, a chemical compound commonly found in red wine and grapes, has been found in previous research studies involving laboratory animals to have a beneficial effect on glucose metabolism. But there have been no formal studies with humans.

The six-week study will focus on 30 subjects between the ages of 50 and 80 who have IGT. Some participants in the double-blind study will receive resveratrol supplements while others will receive a placebo.

The object of the research will be to see resveratrol's effects on blood glucose levels after meals. Further study will look into the chemical compound's effects on muscle cell and blood vessel functions.

Word about resveratrol's beneficial effects has circulated for several years, especially in light of the compound's natural occurrence in red wine. But it turns out that to receive a dose of resveratrol sufficient to affect blood glucose levels, a wine drinker would have to imbibe more than 100 bottles of wine per day-an impossibility from the standpoint of health, finances, and efficiency.

Several manufacturers sell resveratrol supplements, usually in 100 mg, 250 mg, or 500 mg doses. However, nobody is yet certain what should be a standard daily dose and what should be considered an overdose.

(Anecdotal information on the Internet seems to put the upper limit at 5,000 mg daily. Supposed side effects from too much resveratrol can include joint aches and stomach pains. Because the compound is a blood thinner, users are cautioned to tell their doctors if they are also taking prescribed blood thinners.)

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Did you know...

Every 6 seconds, a person dies from diabetes (50 million)*

Source:  International Diabetes Foundation