New-onset diabetes after SARS-CoV-2 infection has been documented.1-4 Milder Omicron variant infection and booster vaccination may mitigate risk, but most available studies predate Omicron emergence and booster rollout.1-3 We estimated risk of new-onset type 2 diabetes (T2D) after SARS-CoV-2 infection among boosted adults during Delta- and Omicron-predominant transmission in Singapore.