International Diabetes News

Dementia-like clumps found in cells before cancer strikes

Cancer Research UK-funded scientists have uncovered dementia-like behavior in pancreas cells at risk of turning into cancer. The findings provide clues that could help in the treatment and prevention of pancreatic cancer, a difficult-to-treat disease linked to 6,900 deaths in the UK every year.*

National registry launched to transform care for people at risk of type 1 diabetes

The UK Islet Autoantibody Registry aims to transform how people in the early ‘hidden’ stages of type 1 diabetes are monitored and supported, and act as a gateway to ground-breaking clinical trials and treatments. The registry – led by Dr Rachel Besser – will track children and adults who have tested positive for type 1 diabetes autoantibodies.

Diabetes Tied to Doubled Risk for Sepsis

People living with type 2 diabetes experience double the risk for incident sepsis versus matched individuals without diabetes, according to a study presented at the annual meeting of the European Association for the Study of Diabetes, held from Sept. 15 to 19 in Vienna.

Hypoglycaemia Rates Drop for Pancreatic Diabetes in Denmark

In a nationwide cohort study of patients with newly diagnosed diabetes, hospitalisations for severe hypoglycaemia among those with pancreatic diabetes dropped significantly from 2003-2006 to 2019-2022. Shifts in treatment patterns, including the increased use of metformin and the transition from human insulin to analogues, likely contributed to this substantial decline, although patients with pancreatic diabetes remained at a notable risk for hypoglycaemia

Glucagon-Like Peptide-1 Receptor Agonists for Preventing Cardiorenal Complications

With the advent of novel glucagon-like peptide-1 receptor agonists (GLP-1 RAs), such as semaglutide, and the discovery of their protective benefit against both adverse cardiovascular and kidney outcomes in large randomized clinical trials (RCTs), there has been intense interest in prescribing these agents for a large proportion of the population. However, it is still unclear through what causal mechanism these benefits may occur.

Clinical Trials

Clinical trials are conducted to collect data regarding the safety and efficacy of new drug and device development. There are several steps and stages of approval in the clinical trials process before a drug or device can be sold in the consumer market, if ever.

You can search for some available information on clinical trials
This study aims to culturally adapt an existing American Diabetes Association (ADA)-recognized diabetes self-management and support or DSMES (Diabetes Self Management Education Support) program (Project Dulce) and integrate an evidence-based text messaging program (Dulce Digital) for implementation in Filipino Americans (FAs) with type 2 diabetes mellitus (T2DM).

Cholesterol Lowering and Residual Risk in Diabetes, Type 1 (CHORD1)

This is a prospective, interventional, cohort study, meaning that researchers will follow and observe a group of enrolled study participants over a period of time (one to two months) to gather information and record any developments of the outcomes in question.

Precision Dosing of Metformin in Youth With T2D (PRECISE_T2D)

The purpose of this study to compare the typically prescribed dose of metformin (1000mg twice a day) with a higher dose of metformin (1350mg twice a day).

A Study to Better Understand the Role of the Hormones Glucagon and Insulin in the Progression of Diabetes

The purpose of this study is to determine the longitudinal effect of diabetes-associated variation in TCF7L2 on a-cell function and the contribution of a-cell function to longitudinal glucose tolerance and EGP in non-diabetic subjects.

Sources: ClinicalTrials.gov and MayoClinic

You can search for some available information on clinical trials